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DOE-HDBK-1109-97
Radiological Safety Training for Radiation-Producing (X-Ray) Devices
Instructor=s Guide
Lesson Plan
Instructor=s Notes
vi. Cell Sensitivity.
Some cells are more sensitive to radiation than
others. Cells that are more sensitive to radiation are
radiosensitive; cells that are less sensitive to
radiation are radioresistant.
The law of Bergonie and Tribondeau states:
The radiosensitivity of a tissue is directly
proportional to its reproductive capacity and
inversely proportional to its degree of
differentiation.
It is generally accepted that cells tend to be
radiosensitive if they are:
1) Cells that have a high division rate
2) Cells that have a high metabolic rate
3) Cells that are of a non-specialized type
4) Cells that are well nourished
The following are radiosensitive tissues:
1) Germinal
2) Hematopoietic
3) Epithelium of the skin
4) Epithelium of the gastrointestinal tract
The following are radioresistant tissues:
1) Bone
2) Liver
3) Kidney
4) Cartilage
5) Muscle
6) Nervous system tissue
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