necessary when handling pyrophoric material. Special
considerations should be given to systems that handle tritium
(see Section 2.10, Tritium Facilities).
Ventilation and cleanup systems associated with the primary
confinement system should not be shared with secondary and
tertiary confinement systems.
Tanks within the primary confinement system should vent to the
off-gas treatment system.
The operating pressure in the primary confinement system should
be negative with respect to the secondary confinement.
Gloveboxes should meet the following criteria:
Corrosive gases or particles from vats, scrubbers, and similar
equipment should be neutralized prior to reaching HEPA off-gas
A single filtered exhaust path should be acceptable when working
with low-toxicity materials that do not require dilution or
Exhaust flow rates (for air-ventilated gloveboxes) should confine
in-box contaminants safely when an access port is opened or a
If the glovebox is filled with an inert atmosphere, specific design
criteria for emergencies (i.e., ruptured glove) should be
incorporated on a case-by-case basis (e.g., pyrophoric materials).
Hot cells should meet the following criteria: