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Page Title:
Table B-IV BeLPT Analysis Using Least Absolute Values -- EHP 1996 |
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|  DOE-SPEC-1142-2001
Table B-IV
BeLPT Analysis Using Least Absolute Values -- EHP 1996
Treatment
Fitted
Residuals
Group
Well Counts
Value
Sm
Day5 controls
1220
2391
1774
947
1453.8
34.9
-18
50
20
-43
Day5 controls
1499
1568
1410
1131
1453.8
34.9
3
8
-3
-25
Day5 controls
969
2265
1743
728
1453.8
34.9
-41
44
18
-69
Day5 Be1
1777
1890
1702
1885
1830.2
5.3
-3
3
-7
3
Day5 Be10
3368
7221
1473
3097
3229.7
70.8
4
80 -79
-4
Day5 Be100
3631
3655
2452
1634
2983.8
34.2
20
20 -20
-60
Day7 controls
3616
17410
3989
3144
3018.0
84.5
18
175
28
4
Day7 controls
669
1257
1497
4460
3018.0
84.5 -151
-88 -70
39
Day7 controls
2897
4174
1366
1152
3018.0
84.5
-4
32 -79
-96
Day7 Be1
1670
2186
629
1264
1452.9
46.9
14
41 -84
-14
Day7 Be10
330
598
254
264
295.2
22.4
11
71 -15
-11
Day7 Be100
3611
4436
14452
14892
8006.8 103.7
-80
-59
59
62
PHA
102156
44221
59346
51090
55063.5
25.2
62
-22
7
-7
CONA
115673 104146
252237 159421 135796.6
36.4
-16
-27
62
16
Fitted Value = exp[median(Ln z)] for each treatment group
NOTE: Sm and residuals are in Ln % units
STIMULATION INDICES (SI)
Day 5
Day 7
D5Be1
D5Be10
D5Be100
D7Be1
D7Be10
D7Be100
PHA
CONA
SI
1.26
2.22
2.05
0.48
0.10
2.65
37.89
93.41
Ln(SI)
0.23
0.80
0.72
-0.73
-2.32
0.98
3.63
4.54
Stan.
1.00
3.48
3.13
-1.25
-3.98
1.67
15.83
19.76
Ln(SI)
NOTE: Standardized Ln(SI) = Ln(SI)/Standard Error is Standardized Ln (SI)
Large POSITIVE value (GT 2.5) Indicates POSITIVE Response
Large NEGATIVE value (LT -2.5) Indicates Cell Killing
Summary Statistics Sm (Coefficient of Variation)* for PM1271
Overall:
0.385
Day 5 Control:
0.349
Day 5 Treated:
0.23
Day 5 Pooled:
0.319
Day 7 Control:
0.845
Day 7 Treated
0.855
Day 7 Pooled:
0.811
*Sm is MAD estimate of the standard deviation on Ln scale (corresponds to CV on original scale)
B.10. REFERENCE DATA SET FOR EACH SERUM
B.10.1. For the tritiated thymidine BeLPT, the laboratory shall maintain a reference data
set based on at least 30 acceptable (Section 8.3) unexposed and/or normal
BeLPTs for each serum. The data for each BeLPT in the reference data set shall
be retained and used to evaluate all subsequent BeLPTs in that serum. The
maximum SI for these "normal" individuals is assumed to follow a normal
17
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