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| DOE-HDBK-1184-2004
= st
=k
=k
k
k
k
TAI3 , blood
Tbbseq , TLNth
bbseq , LNth
TBB1 , TET2
BB1 , ET2
=k
=k
= st
k
k
k
TBBseq , TLNth
BBseq , LNth
Tbb2 , TBB1
bb2 , BB1
TLNth, blood
=k
= st
= st
k
k
k
Tbb1 , TBB1
bb1 , BB1
Tbbseq , blood
TBB1 , blood
= st
= st
k
k
TBBseq , blood
Tbb2 , blood
= st
= st
k
k
Tbb1 , blood
TLNet , blood
The transfer rate constants for the systemic compartments, urine, feces, and other excreta are
defined:
= 12
1.4 ln(2)
ln(2)
k
bladder, urine
=
⋅
= 0.03⋅
k
k
hto, bladder
blood , obt
3
10
0.25
0.1 ln(2)
ln(2)
=
⋅
= 0.97⋅
k
k
hto, ULI
blood , hto
3
10
0.25
ln(2)
1.5 ln(2)
=
=
⋅
k
k
obt , bladder
hto, excreta
40
3
10
Finally, the transfer rate constants for the GI tract are defined:
= 24
k
S, SI
=6
k
SI , ULI
⋅f
k
SI , ULI 1
=
k
SI , blood
1 - f1
24
=
k
ULI , LLI
13
=1
k
LLI, feces
72
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