Fisher-Modified Wrenn-Lipsztein Uranium Urinary Excretion Model

DOE-STD-1136-2004

Guide of Good Practices for Occupational Radiological Protection in Uranium Facilities

Table 5 -11. ICRP Publication 30 Uranium Urinary Excretion Parameter Values(a)

Biological Half- Life (d)

Coefficient (d-1)

Compartment

1.5

0.25

2.77x10-2

6.93x10-3

4.62x10-7

1,500

3.19x10-6

5,000

(a) (ICRP 1979 and 1988b)

5.6.3.5 Fisher-Modified Wrenn-Lipsztein Uranium Urinary Excretion Model

As discussed above, this model (given in Equation 5.2) represents a modification of the clearance

half-times in the ICRP Publication 30 respiratory tract model and in the Wrenn-Lipsztein recycling model

for systemic uranium. In an effort to simplify this recycling model, Fisher et al. also derived a five-

compartment model to fit the curve predicted by the above-mentioned Fisher-Modified Wrenn-Lipsztein

function. The replacement function that describes this five-compartment model is as follows:

(5.4)

where eiu(t) is the urine excretion rate per unit intake and t is the time in days after intake of uranium.

The parameter values for this replacement function are given in Table 5-12.

Table 5 -12. Parameter Values for the Replacement Function for the Fisher-Modified Wrenn-Lipsztein

Uranium Model(a)

Fractional Uptake

Excretion

Residence

from Transfer

Constant

Halftime

Compartment

(d-1)

Compartment

(d)

Transfer

0.673

2.77

0.25

1.1

Kidneys and

0.15

0.116

0.02

soft tissues

0.07

0.0267

0.15

0.00231

300

Bone volume

0.02

0.000187

3,700

(a) (Fisher et al., 1991)

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