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  | ![]() DOE-HDBK-1130-98 
In general, the greater the dose, the greater the potential for biological effects. 
b. Dose rate (how fast) 
The faster the dose is delivered, the less time the body has to repair itself. 
c. Type of radiation 
For example, internally deposited alpha emitters are more damaging than beta 
or gamma emitters for the same energy deposited. 
d. Area of the body that receives a dose 
In general, the larger the area of the body that receives a dose, the greater the 
biological effect. 
Extremities are less sensitive than blood forming and other critical organs. That 
is why the annual dose limit for extremities is higher than for a whole body dose 
that irradiates internal organs. 
e. Cell sensitivity 
The most sensitive cells are those that are rapidly dividing. Examples include 
blood cells, hair follicles, and the cells lining the gastrointestinal tract. 
f. 
Individual sensitivity 
Some individuals are more sensitive to environmental factors such as ionizing 
radiation. 
The developing embryo/fetus is the most sensitive, and children are more 
sensitive than adults. 
In general, the human body becomes relatively less sensitive to ionizing 
radiation with increasing age. The exception is that elderly people are more 
sensitive than middle-aged adults due to the inability to repair damage as 
quickly (less efficient cell repair mechanisms). 
D. Prenatal Radiation Exposure 
Although no effects were seen in Japanese children conceived after the atomic bomb, there 
were effects seen in some children who were in the womb when exposed to the atomic 
bomb radiation at Hiroshima and Nagasaki. Some of these children were born with a 
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