Figure 1. Alternative Logic Flow Chart for Determining

DOE-STD-1121-98

Number of independent sources = n

Do this for each source j:

What is

Possible multiple

Single

or chronic

or rare

intake?

Does

j clear

pj = 0

rapidly?

Yes

AMDDj = IL

pj = 1

Do this for each source j:

IF pj = 1, AMDDj = IL / (Σ {j=1 to n} pj)

Calculate DILj

Figure 1. Alternative Logic Flow Chart for Determining the "Acceptable Minimum

Detectable Dose" (AMDD) and DIL for Each Radionuclide or Group of Radionuclides

When Exposure to Multiple, Independent Sources Is Possible

intakes resulting in the AMDD for group j. This detection sensitivity or minimum change in amount,

)Amin, is given by

(5)

where AMDDj is substituted for the IL, and the other terms are as defined above. This formalism accounts

for the problem of multiple independent sources.

The sampling frequency that makes minimum demands on analytical technology in terms of its

detection sensitivity for analyte in bioassay samples is that frequency for which the )Amin is maximized.

This sampling frequency can be found by setting